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991.
Circular dichroism (CD) spectra of non-covalent ligand : biomolecule couples contain information on the equilibrium geometries of the associated structures that can be retrieved upon comparison of the sign and intensity of the experimental CD bands with the quantum mechanically calculated rotational strengths of low energy supramolecular complexes, obtained from molecular modelling methods. For both chiral and achiral ligands this approach proved useful to reach a structure based rationale of ground and excited state properties of the non-covalent ligand : protein associates. In this Perspective we illustrate the potential of this method focusing on the main achievements of our recent spectroscopic, conformational and photochemical studies on drug-albumin complexes and collocate it in the frame of current methodologies of molecular modelling and spectroscopic investigation of ligand : biomolecule binding. 相似文献
992.
Shinkevich E Deblander J Matthijs S Jacobs J De Kimpe N Tehrani KA 《Organic & biomolecular chemistry》2011,9(2):538-548
1,2-Disubstituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones are prepared for the first time through an activated Pictet-Spengler reaction of the corresponding imines of 2-(1,4-dimethoxynaphth-2-yl)ethylamine in the presence of an acyl chloride and AlCl(3) followed by an oxidation with silver(II) oxide in nitric acid. Depending on the reaction conditions the N-trichloroacetyl protecting group could be cleaved off, converted to an N-methoxycarbonyl group or transformed to an N-(2-oxoacetamide) moiety. The synthesized 1,2-disubstituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones constitute a new class of quinones, which has not been reported yet. 相似文献
993.
Li X Chen G Schinzel S Siegbahn PE 《Dalton transactions (Cambridge, England : 2003)》2011,40(42):11296-11307
Two artificial water oxidation catalysts, the blue dimer and the Llobet catalyst, have been studied using hybrid DFT methods. The results are compared to those for water oxidation in the natural photosystem II enzyme. Studies on the latter system have now reached a high level of understanding, at present much higher than the one for the artificial systems. A recent high resolution X-ray structural investigation of PSII has confirmed the main features of the structure of the oxygen evolving complex (OEC) suggested by previous DFT cluster studies. The O-O bond formation mechanism suggested is of direct coupling (DC) type between an oxygen radical and a bridging oxo ligand. A similar DC mechanism is found for the Llobet catalyst, while an acid-base (AB) mechanism is preferred for the blue dimer. All of them require at least one oxygen radical. Full energy diagrams, including both redox and chemical steps, have been constructed illustrating similarities and differences to the natural system. Unlike previous DFT studies, the results of the present study suggest that the blue dimer is rate-limited by the initial redox steps, and the Llobet catalyst by O(2) release. The results could be useful for further improvement of the artificial systems. 相似文献
994.
Two novel alkaloids, wilsoniamines A and B, both possessing a hexahydropyrrolo[1,2-c]imidazol-1-one ring system that has not previously been found in nature, together with a new alkaloid, amathamide H and a known alkaloid, amathamide C were isolated from the temperate Australian bryozoan, Amathia wilsoni. MS and NMR analysis established the structure of the new compounds and indicated that the structure of amathamide C and several related compounds be revised. Amathamides C and H showed moderate anti-malarial and anti-trypanosomal activity. 相似文献
995.
La Deda M Crispini A Aiello I Ghedini M Amati M Belviso S Lelj F 《Dalton transactions (Cambridge, England : 2003)》2011,40(19):5259-5270
Four cyclometalated Pt(IV) compounds, 1a,b and 2a,b, were successfully obtained by oxidative addition of I(2) to 2-phenylpyridinate (PhPy) and Nile Red (NR) derived Pt(II) complexes with acetylacetonate (acac) or hexafluoroacetylacetonate (hacac) ancillary ligands. Single crystal X-ray diffraction, electrochemical, photophysical and computational studies have been performed in comparison with the analogues Pt(II) compounds, shedding new light on the role of the oxidation state of the metal centre towards both the luminescence properties and the dioxygen quenching. 相似文献
996.
Manet I Manoli F Donzello MP Viola E Andreano G Masi A Cellai L Monti S 《Organic & biomolecular chemistry》2011,9(3):684-688
A water soluble Zn(II) porphyrazine drives the conformational equilibrium of the G-quadruplex of a human telomeric sequence exclusively towards a parallel conformation upon complexation. 相似文献
997.
Li W Estrada-de los Santos P Matthijs S Xie GL Busson R Cornelis P Rozenski J De Mot R 《Chemistry & biology》2011,18(10):1320-1330
Under control of the Gac regulatory system, Pseudomonas putida RW10S1 produces promysalin to promote its own swarming and biofilm formation, and to selectively inhibit many other pseudomonads, including the opportunistic pathogen Pseudomonas aeruginosa. This amphipathic antibiotic is composed of salicylic acid and 2,8-dihydroxymyristamide bridged by a unique 2-pyrroline-5-carboxyl moiety. In addition to enzymes for salicylic acid synthesis and activation, the biosynthetic gene cluster encodes divergent type II fatty acid biosynthesis components, unusual fatty acid-tailoring enzymes (two Rieske-type oxygenases and an amidotransferase), an enzyme resembling a proline-loading module of nonribosomal peptide synthetases, and the first prokaryotic member of the BAHD family of plant acyltransferases. Identification of biosynthetic intermediates enabled to propose a pathway for synthesis of this bacterial colonization factor. 相似文献
998.
Maçôas E Marcelo G Pinto S Cañeque T Cuadro AM Vaquero JJ Martinho JM 《Chemical communications (Cambridge, England)》2011,47(26):7374-7376
A symmetric cationic molecule with D-π-A(+)-π-D architecture was synthesized with high two-photon absorption cross-section (σ(2) ≈ 1140 GM). Application as a marker in fluorescence microscopy of living cells revealed its presence inside the cell staining vesicular shape organelles in the cytoplasm. Fluorescence lifetime imaging microscopy shows that it is also able to penetrate within the nucleus. 相似文献
999.
Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections 总被引:1,自引:0,他引:1
Fechner H Pinkert S Geisler A Poller W Kurreck J 《Molecules (Basel, Switzerland)》2011,16(10):8475-8503
Subtype B coxsackieviruses (CVB) represent the most commonly identified infectious agents associated with acute and chronic myocarditis, with CVB3 being the most common variant. Damage to the heart is induced both directly by virally mediated cell destruction and indirectly due to the immune and autoimmune processes reacting to virus infection. This review addresses antiviral therapeutics for cardiac coxsackievirus infections discovered over the last 25 years. One group represents pharmacologically active low molecular weight substances that inhibit virus uptake by binding to the virus capsid (e.g., pleconaril) or inactivate viral proteins (e.g., NO-metoprolol and ribavirin) or inhibit cellular proteins which are essential for viral replication (e.g., ubiquitination inhibitors). A second important group of substances are interferons. They have antiviral but also immunomodulating activities. The third and most recently discovered group includes biological and cellular therapeutics. Soluble receptor analogues (e.g., sCAR-Fc) bind to the virus capsid and block virus uptake. Small interfering RNAs, short hairpin RNAs and antisense oligonucleotides bind to and led to degradation of the viral RNA genome or cellular RNAs, thereby preventing their translation and viral replication. Most recently mesenchymal stem cell transplantation has been shown to possess antiviral activity in CVB3 infections. Taken together, a number of antiviral therapeutics has been developed for the treatment of myocardial CVB infection in recent years. In addition to low molecular weight inhibitors, biological therapeutics have become promising anti-viral agents. 相似文献
1000.
Osburn S Steill JD Oomens J O'Hair RA van Stipdonk M Ryzhov V 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(3):873-879
The structure and reactivity of the cysteine methyl ester radical cation, CysOMe.+, have been examined in the gas phase using a combination of experiment and density functional theory (DFT) calculations. CysOMe.+ undergoes rapid ion–molecule reactions with dimethyl disulfide, allyl bromide, and allyl iodide, but is unreactive towards allyl chloride. These reactions proceed by radical atom or group transfer and are consistent with CysOMe.+ possessing structure 1 , in which the radical site is located on the sulfur atom and the amino group is protonated. This contrasts with DFT calculations that predict a captodative structure 2 , in which the radical site is positioned on the α carbon and the carbonyl group is protonated, and that is more stable than 1 by 13.0 kJ mol?1. To resolve this apparent discrepancy the gas‐phase IR spectrum of CysOMe.+ was experimentally determined and compared with the theoretically predicted IR spectra of a range of isomers. An excellent match was obtained for 1 . DFT calculations highlight that although 1 is thermodynamically less stable than 2 , it is kinetically stable with respect to rearrangement. 相似文献